The first drug-coated vascular coated stent to treat central venous lesions in China was successfully enrolled in the first case in West China.
时间: 2024-03-25
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Recently, the first drug-coated vascular coated stent for central venous lesions in China, a national prospective, multicenter, randomized controlled clinical trial with the Department of Vascular Surgery of West China Hospital of Sichuan University as the co-leader, was completed by the team of Prof. Zhao Jichun of the Department of Vascular Surgery and Prof. Cui Tianlei of the Department of Nephrology of West China Hospital of Sichuan University. The first case enrolled in our center marked the clinical trial project entered the full implementation stage.


According to statistics, by the end of 2022, the total number of dialysis in China reached 1 million, of which more than 800,000 were hemodialysis patients. Central venous stenosis or occlusion is one of the major complications of hemodialysis patients, which seriously affects the quality of dialysis for patients. Currently, the preferred treatment is endoluminal treatment, and most of them adopt intravascular luminal balloon dilatation treatment, but with simple balloon dilatation, the blood vessels are prone to retraction and restenosis and thrombosis, and the long-term patency is poor, and currently there is a lack of laminar stents for central venous stenosis on the market in China.

The novel drug-coated vascular coated stent in this study is a specialized stent developed for central venous lesions. The product combines good support and suppleness, and the stent surface coated with membrane and coating can provide better patency. Meanwhile, the stent is equipped with a stable and reliable delivery system, which will provide a safe and effective solution for clinical use.
The first patient enrolled was an arteriovenous endovascular fistula dialysis patient who had been on dialysis for 6 years and was admitted to the hospital with swelling of the right upper extremity for many days. The patient's right innominate vein was severely stenotic after endovascular angiography. After randomization to the experimental group, after careful evaluation and preparation by the research team, Prof. Cui Tianlei's team successfully completed the implantation of drug-coated vascular coated stent in the nameless vein, which relieved the severe stenosis lesion, restored the smooth venous return of the right upper extremity, and eliminated the patient's limb swelling, with a significant clinical treatment effect. The investigators fully affirmed the use and clinical performance of the coated stent.

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Comparison of preoperative and postoperative images of the patient

A prospective, multicenter, randomized controlled clinical trial of the safety and efficacy of a drug-coated vascular overlay stent system for the treatment of central venous stenosis or occlusive lesions was conducted by the West China Hospital of Sichuan University and the First Affiliated Hospital of Chongqing Medical University as the co-leaders of the trial, which included 10 participating units, including the Guangdong Provincial People's Hospital, the Gaozhou City People's Hospital, the First Affiliated Hospital of Guangxi Medical University, the Affiliated Tumor Hospital of Guizhou Medical University, the Guilin The Affiliated Hospital of Guizhou Medical University, Guilin Medical College Hospital, Suzhou Municipal Hospital, Wuhan Central Hospital, and Shaw Hospital of Zhejiang University are the 10 participating units, and 154 subjects are planned to be included in the randomized controlled clinical trial.

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专家介绍




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Prof. Jichun Zhao

Chief Physician, Professor

Supervisor of doctoral students

Director of Vascular Surgery, West China Hospital, Sichuan University

Executive Director of the Chinese Society of Geriatrics and President of the Peripheral Vascular Disease Management Branch

Vice Chairman of Vascular Surgery Physicians Branch, Chinese Medical Doctors Association (CMA)

Vice Chairman of the Vascular Surgery Committee of the National Specialized Committee on Cardiovascular Diseases (NSCVD)

Vice President, Asia-Pacific Vascular Academic Alliance

Vice President, International Vascular Federation China

Vice Chairman, Specialized Committee on Retroperitoneal and Pelvic Floor Diseases, Chinese Research Hospitals

Academic Committee of the National Center for Clinical Research on Radiation and Therapy (NCCRT)

Member of Chinese Medical Association Vascular Surgery Group

Academic and Technical Leaders of Sichuan Province

Sichuan Province "Tianfu Qingcheng Program" Tianfu Famous Doctors

President of Sichuan Physicians Association Vascular Surgery Physicians Branch

Chairman, Vascular Surgery Group, Sichuan Provincial Medical Association

He is the deputy editor-in-chief of Chinese Basic and Clinical Journal of General Surgery, Journal of Vascular and Endoluminal Vascular Surgery, Chinese Journal of Vascular Surgery (Electronic Edition), and deputy editor-in-chief of Chinese Journal of Vascular Surgery. He has been awarded 3 first prizes and 1 second prize for provincial scientific and technological progress achievements, and has received national, ministerial and provincial funding. He has published more than 230 academic papers, including more than 90 SCI papers.

In the diagnosis, surgery and minimally invasive endoluminal vascular treatment of vascular surgical diseases, especially in ruptured abdominal aortic aneurysm surgery and endoluminal treatment, high-risk abdominal aortic aneurysm surgery and endoluminal repair, surgical and endoluminal hybridization of thoracic and abdominal aortic aneurysm and coarctation, surgical treatment of complex carotid artery aneurysm, peripheral vascular disease in diabetic foot, thrombosed arterial vein-related diseases and retroperitoneal tumor resection and arterial reconstruction involving large blood vessels. The research on arterial reconstruction for liver transplantation is in-depth and at an advanced level both at home and abroad.



 Reprinted from Hi-Hearts