Vasco Knight@LINC 2024 | Optimizing Drug Technology Efficacy: Practical Challenges and Strategies for Paclitaxel DES in Complex Femoropopliteal Lesions
时间: 2025-04-14
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Speaker: Masahiko Fujihara, MD

Hospital: Kishiwada Tokushukai Hospital, Osaka, Japan

 

Abstract

 

This study analyzed real-world outcomes of paclitaxel DES in complex femoropopliteal lesions. While DES showed superior patency (72.7% at 3 years), concerns about aneurysmal degeneration (16.8% at 1 year) and reintervention complexity limit its adoption.

 

Introduction

 

Despite trial success, real-world DES use faces challenges. CAPSICUM registry data and case studies highlight the balance between efficacy and complications.

 

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Case Studies

 

Aneurysmal Degeneration

 

IVUS-guided oversizing (MLA>28 mm²) correlated with 16.8% aneurysm risk.

 

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Drug-with-Drug (DWD) Strategy

 

DES+DCB achieved 85.3% 1-year patency, with diffuse restenosis (67%).

 

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Conclusion

 

1.DES remains effective for long lesions but requires cautious deployment.

 

2.DWD may reduce occlusive restenosis and simplify reinterventions.

 

3.Technical refinements and post-procedural monitoring are critical.


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